AGO2 silences mobile transposons in the nucleus of quiescent cells
AGO2 silences mobile transposons in the nucleus of quiescent cells
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet little is known about its regulation in vivo. Here we show that in quiescent mouse splenocytes, AGO2 localizes almost exclusively to the nucleus. AGO2 subcellular localization is modulated by the Pi3K–AKT–mTOR pathway, a well-est...
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Full title
AGO2 silences mobile transposons in the nucleus of quiescent cells
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TN_cdi_proquest_miscellaneous_2892272338
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2892272338
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-023-01151-z
