Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
About this item
Full title
Author / Creator
Qi, Tao , Wang, Yao , Yang, Yuan , Gao, Siqi , Liu, Jingtong , Huang, Qiang , Tian, Yuwen , Tang, Junnan , Zheng, Wei V. and Wang, Yongming
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been developed, many genomic loci still could not be edited due to a lack of protospacer adjacent motifs (PAMs). We previously developed a compact SlugCas9 recognizing an NNGG PAM. Here we demonstrate that SlugCas9 displays comparabl...
Alternative Titles
Full title
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2898957400
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2898957400
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-023-01481-5
