Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates...
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational design of preventative therapies. Here we report a set of methods for the detection, quantification, and characterisation of soluble aggregates in conditioned media of cerebral organoids derived from h...
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Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
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TN_cdi_proquest_miscellaneous_2902940200
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2902940200
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1359-4184,1476-5578
E-ISSN
1476-5578
DOI
10.1038/s41380-023-02333-3
