Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy
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Full title
Author / Creator
Gillmore, Julian D. , Judge, Daniel P. , Cappelli, Francesco , Fontana, Marianna , Garcia-Pavia, Pablo , Gibbs, Simon , Grogan, Martha , Hanna, Mazen , Hoffman, James , Masri, Ahmad , Maurer, Mathew S. , Nativi-Nicolau, Jose , Obici, Laura , Poulsen, Steen Hvitfeldt , Rockhold, Frank , Shah, Keyur B. , Soman, Prem , Garg, Jyotsna , Chiswell, Karen , Xu, Haolin , Cao, Xiaofan , Lystig, Ted , Sinha, Uma , Fox, Jonathan C. and ATTRibute-CM Investigators
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
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Scope and Contents
Contents
Transthyretin amyloid cardiomyopathy is characterized by the deposition of misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR stabilizer that acts to inhibit dissociation of tetrameric TTR and leads to more than 90% stabilization across the dosing interval as measured ex vivo.
In this phase 3, double-blind tr...
Alternative Titles
Full title
Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy
Authors, Artists and Contributors
Author / Creator
Judge, Daniel P.
Cappelli, Francesco
Fontana, Marianna
Garcia-Pavia, Pablo
Gibbs, Simon
Grogan, Martha
Hanna, Mazen
Hoffman, James
Masri, Ahmad
Maurer, Mathew S.
Nativi-Nicolau, Jose
Obici, Laura
Poulsen, Steen Hvitfeldt
Rockhold, Frank
Shah, Keyur B.
Soman, Prem
Garg, Jyotsna
Chiswell, Karen
Xu, Haolin
Cao, Xiaofan
Lystig, Ted
Sinha, Uma
Fox, Jonathan C.
ATTRibute-CM Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2913081098
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2913081098
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2305434
