Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
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Author / Creator
Wang, Han , Yin, Peng , Zheng, Tingting , Qin, Lanju , Li, Shihua , Han, Pu , Qu, Xiao , Wen, Jun , Ding, Haoyi , Wu, Jiahao , Kong, Tianxiang , Gao, Zhengrong , Hu, Songtao , Zhao, Xin , Cao, Xiangyu , Fang, Min , Qi, Jianxun , Xi, Jianzhong Jeff , Duan, Kai , Yang, Xiaoming , Zhang, Zhuobing , Wang, Qihui , Tan, Wenjie and Gao, George Fu
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The global outbreak of the mpox virus (MPXV) in 2022 highlights the urgent need for safer and more accessible new-generation vaccines. Here, we used a structure-guided multi-antigen fusion strategy to design a ‘two-in-one’ immunogen based on the single-chain dimeric MPXV extracellular enveloped virus antigen A35 bivalently fused with the intracellu...
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Full title
Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
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Record Identifier
TN_cdi_proquest_miscellaneous_2915572240
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2915572240
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01715-7
