Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
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Author / Creator
Guo, Rui , Liu, Jianping , Min, Xia , Zeng, Wen , Shan, Bing , Zhang, Mengmeng , He, Zhuohao , Zhang, Yaoyang , He, Kaiwen , Yuan, Junying and Xu, Daichao
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging induces autophagy decline. Here we show the role of protein
S
-palmitoylation in autophagy. We identify the palmitoyl acyltransferase DHHC5 as a regulator of autophagy by mediating the palmitoyla...
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Full title
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
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TN_cdi_proquest_miscellaneous_2928242651
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2928242651
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ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-023-01163-9
