Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors
Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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In some cancers mutant p53 promotes the occurrence, development, metastasis and drug resistance of tumours, with targeted protein degradation seen as an effective therapeutic strategy. However, a lack of specific autophagy receptors limits this. Here, we propose the synthesis of biomimetic nanoreceptors (NRs) that mimic selective autophagy receptor...
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Full title
Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors
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TN_cdi_proquest_miscellaneous_2929033038
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2929033038
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ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/s41565-023-01562-5
