Screening oral drugs for their interactions with the intestinal transportome via porcine tissue expl...
Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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In vitro systems that accurately model in vivo conditions in the gastrointestinal tract may aid the development of oral drugs with greater bioavailability. Here we show that the interaction profiles between drugs and intestinal drug transporters can be obtained by modulating transporter expression in intact porcine tissue explants via the ultrasoun...
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Full title
Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning
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TN_cdi_proquest_miscellaneous_2929538144
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2929538144
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ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-023-01128-9
