Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Although long noncoding RNAs (lncRNAs) dominate the transcriptome, their functions are largely unexplored. The extensive overlap of lncRNAs with coding and regulatory sequences restricts their systematic interrogation by DNA-directed perturbation. Here we developed genome-scale lncRNA transcriptome screening using Cas13d/CasRx. We show that RNA tar...
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Full title
Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
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TN_cdi_proquest_miscellaneous_2932437282
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2932437282
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-024-02190-0
