ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation...
ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2
About this item
Full title
Author / Creator
Luo, Maowu , Bao, Lei , Xue, Yuanyuan , Zhu, Ming , Kumar, Ashwani , Xing, Chao , Wang, Jennifer E , Wang, Yingfei and Luo, Weibo
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrog...
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Full title
ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_2958295162
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2958295162
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI171166
