GPCR-IPL score: multilevel featurization of GPCR–ligand interaction patterns and prediction of ligan...
GPCR-IPL score: multilevel featurization of GPCR–ligand interaction patterns and prediction of ligand functions from selectivity to biased activation
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Publisher
England: Oxford University Press
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Language
English
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England: Oxford University Press
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Abstract
G-protein-coupled receptors (GPCRs) mediate diverse cell signaling cascades after recognizing extracellular ligands. Despite the successful history of known GPCR drugs, a lack of mechanistic insight into GPCR challenges both the deorphanization of some GPCRs and optimization of the structure–activity relationship of their ligands. Notab...
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Full title
GPCR-IPL score: multilevel featurization of GPCR–ligand interaction patterns and prediction of ligand functions from selectivity to biased activation
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TN_cdi_proquest_miscellaneous_2974007915
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2974007915
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ISSN
1467-5463
E-ISSN
1477-4054
DOI
10.1093/bib/bbae105
