Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
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Author / Creator
HELIOS-B Trial Investigators , Fontana, Marianna , Berk, John L. , Gillmore, Julian D. , Witteles, Ronald M. , Grogan, Martha , Drachman, Brian , Damy, Thibaud , Garcia-Pavia, Pablo , Taubel, Jorg , Solomon, Scott D. , Sheikh, Farooq H. , Tahara, Nobuhiro , González-Costello, José , Tsujita, Kenichi , Morbach, Caroline , Pozsonyi, Zoltán , Petrie, Mark C. , Delgado, Diego , Van der Meer, Peter , Jabbour, Andrew , Bondue, Antoine , Kim, Darae , Azevedo, Olga , Hvitfeldt Poulsen, Steen , Yilmaz, Ali , Jankowska, Ewa A. , Algalarrondo, Vincent , Slugg, Andrew , Garg, Pushkal P. , Boyle, Katherine L. , Yureneva, Elena , Silliman, Nancy , Yang, Lilli , Chen, Jihong , Eraly, Satish A. , Vest, John and Maurer, Mathew S.
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
United States: Massachusetts Medical Society
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More information
Scope and Contents
Contents
Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin.
In this double-blind, randomized trial, we assigned patients with ATTR-CM in a 1:1 ratio to receive vutrisiran (25 mg) or placebo...
Alternative Titles
Full title
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
Authors, Artists and Contributors
Author / Creator
Fontana, Marianna
Berk, John L.
Gillmore, Julian D.
Witteles, Ronald M.
Grogan, Martha
Drachman, Brian
Damy, Thibaud
Garcia-Pavia, Pablo
Taubel, Jorg
Solomon, Scott D.
Sheikh, Farooq H.
Tahara, Nobuhiro
González-Costello, José
Tsujita, Kenichi
Morbach, Caroline
Pozsonyi, Zoltán
Petrie, Mark C.
Delgado, Diego
Van der Meer, Peter
Jabbour, Andrew
Bondue, Antoine
Kim, Darae
Azevedo, Olga
Hvitfeldt Poulsen, Steen
Yilmaz, Ali
Jankowska, Ewa A.
Algalarrondo, Vincent
Slugg, Andrew
Garg, Pushkal P.
Boyle, Katherine L.
Yureneva, Elena
Silliman, Nancy
Yang, Lilli
Chen, Jihong
Eraly, Satish A.
Vest, John
Maurer, Mathew S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_3099804081
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3099804081
Other Identifiers
ISSN
0028-4793,1533-4406
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2409134
