Possibilities and Limitations in Substituting anti-Drug Antibody Titers with Signal-to-Noise Ratios:...
Possibilities and Limitations in Substituting anti-Drug Antibody Titers with Signal-to-Noise Ratios: A Comprehensive Comparison Using Two Clinical Trial Datasets of Adalimumab
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Author / Creator
Jang, Dawon , Kim, Jaeil , Jo, Youngwon , Lee, Hyuna , Go, Ahra , Kim, Jieun and Choi, Soyoung
Publisher
Cham: Springer International Publishing
Journal title
Language
English
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Publication information
Publisher
Cham: Springer International Publishing
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Scope and Contents
Contents
Immunogenicity assessment is vital in clinical trials and is measured through a multi-tiered approach (screening, confirmatory and titer assays). However, recent studies have suggested that titer results could be reported from ADA signal-to-noise ratios (S/N ratios=sample mean signal/negative control mean signal). More data analysis using two clini...
Alternative Titles
Full title
Possibilities and Limitations in Substituting anti-Drug Antibody Titers with Signal-to-Noise Ratios: A Comprehensive Comparison Using Two Clinical Trial Datasets of Adalimumab
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Record Identifier
TN_cdi_proquest_miscellaneous_3130828002
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3130828002
Other Identifiers
ISSN
1550-7416
E-ISSN
1550-7416
DOI
10.1208/s12248-024-00991-x
