Design, Synthesis and Biological Exploration of Novel N -(9-Ethyl-9 H -Carbazol-3-yl)Acetamide-Linke...
Design, Synthesis and Biological Exploration of Novel N -(9-Ethyl-9 H -Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (M pro ), Spike Glycoprotein and RdRp
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65-89%) via
-alkylation of benzofuran-based triazoles with 2-bromo-
-(9-ethyl-9
-carbazol-3-yl)acetamide. The inhibitory potency of the synthesized compounds against SARS-CoV-2 was evaluated by enacting molecular docking against it...
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Full title
Design, Synthesis and Biological Exploration of Novel N -(9-Ethyl-9 H -Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (M pro ), Spike Glycoprotein and RdRp
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TN_cdi_proquest_miscellaneous_3146911522
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3146911522
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms252312708
