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Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity aft...

Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity aft...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3153177548

Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity after immunization with self-amplifying RNA expressing the spike (S) protein of SARS-CoV-2 in mouse models

About this item

Full title

Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity after immunization with self-amplifying RNA expressing the spike (S) protein of SARS-CoV-2 in mouse models

Publisher

Netherlands: Elsevier Ltd

Journal title

Vaccine, 2024-01, Vol.42 (3), p.608-619

Language

English

Formats

Publication information

Publisher

Netherlands: Elsevier Ltd

More information

Scope and Contents

Contents

Highlights•saRNA vaccines for SARS-CoV-2: Protection & Pathology in mice. •Post-challenge lung pathology in vaccinated mice linked to T- and B-cell infiltration. •T-cell depletion reduces pathology but delays virus clearance.

Alternative Titles

Full title

Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity after immunization with self-amplifying RNA expressing the spike (S) protein of SARS-CoV-2 in mouse models

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_3153177548

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3153177548

Other Identifiers

ISSN

0264-410X

E-ISSN

1873-2518

DOI

10.1016/j.vaccine.2023.12.052

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