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N-Glycoside of Indolo2,3-apyrrolo3,4-ccarbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell...

N-Glycoside of Indolo2,3-apyrrolo3,4-ccarbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3153871171

N-Glycoside of Indolo2,3-apyrrolo3,4-ccarbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction

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Full title

N-Glycoside of Indolo2,3-apyrrolo3,4-ccarbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction

Journal title

Pharmaceuticals (Basel, Switzerland), 2024-12, Vol.17 (12)

Language

English

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More information

Scope and Contents

Contents

Background/Objectives: Indolo[2,3-a]pyrrolo[3,4-c]carbazole scaffold is successfully used as an efficient structural motif for the design and development of different antitumor agents. In this study, we investigated the anti-glioblastoma therapeutic potential of glycosylated indolocarbazole analog LCS1269 utilizing in vitro, in vivo, and in silico...

Alternative Titles

Full title

N-Glycoside of Indolo2,3-apyrrolo3,4-ccarbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction

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Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_3153871171

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3153871171

Other Identifiers

ISSN

1424-8247

E-ISSN

1424-8247

DOI

10.3390/ph17121642

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