Impact of Various Forced Oxidative Stress Factors in Rapid Degradation of mAb: Trastuzumab as a Case...
Impact of Various Forced Oxidative Stress Factors in Rapid Degradation of mAb: Trastuzumab as a Case Study
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Publisher
New York: Springer US
Journal title
Language
English
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Publication information
Publisher
New York: Springer US
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Scope and Contents
Contents
Purpose
Therapeutic monoclonal antibodies (mAbs) are prone to degradation via aggregation and fragmentation. In this study, forced degradation of trastuzumab (TmAb) was explored in saline and
in-vitro
models having H
2
O
2
and exposed to UV light (case study 1)
,
both bleomycin (BML) formulation and ferrous ions (Fe
2+...
Alternative Titles
Full title
Impact of Various Forced Oxidative Stress Factors in Rapid Degradation of mAb: Trastuzumab as a Case Study
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Record Identifier
TN_cdi_proquest_miscellaneous_3159439319
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3159439319
Other Identifiers
ISSN
0724-8741,1573-904X
E-ISSN
1573-904X
DOI
10.1007/s11095-025-03816-4
