OMEGA-guided DNA polymerases enable random mutagenesis in a tunable window
OMEGA-guided DNA polymerases enable random mutagenesis in a tunable window
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England: Elsevier Ltd
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English
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England: Elsevier Ltd
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HighlightsAn innovative obligate mobile element guided activity (OMEGA)-R system integrates SpyCatcher-enIscB and PolI3M-TBD-SpyTag, offering superior performance in targeted random mutagenesis compared with existing technologies. OMEGA-R achieves a mutation rate of 1.4 × 10 –5 base pairs per generation and an extended window length, crucial for co...
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OMEGA-guided DNA polymerases enable random mutagenesis in a tunable window
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TN_cdi_proquest_miscellaneous_3176681563
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3176681563
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ISSN
0167-7799,1879-3096
E-ISSN
1879-3096
DOI
10.1016/j.tibtech.2025.02.011
