Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
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Publisher
England
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Language
English
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Publisher
England
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Contents
Constitutive activation of STING by gain-of-function mutations triggers manifestation of the systemic autoinflammatory disease STING-associated vasculopathy with onset in infancy (SAVI). In order to investigate the role of signaling by tumor necrosis factor (TNF) in SAVI, we used genetic inactivation of TNF receptors 1 and 2 in murine SAVI, which i...
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Full title
Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
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TN_cdi_proquest_miscellaneous_3179851546
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3179851546
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.101350
