Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntingt...
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models
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England
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Language
English
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Publisher
England
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Contents
While progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington's disease (HD), the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-seq), we show that the huntingtin protein (HTT) reproducibly occupies specific locations in the mouse genome. St...
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Full title
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models
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TN_cdi_proquest_miscellaneous_3188433392
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3188433392
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ISSN
1754-8403,1754-8411
E-ISSN
1754-8411
DOI
10.1242/dmm.052282
