DNA demethylating agents suppress preclinical models of synovial sarcoma
DNA demethylating agents suppress preclinical models of synovial sarcoma
About this item
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Author / Creator
Hasegawa, Nobuhiko , Benabdallah, Nezha S. , Smith-Fry, Kyllie , Li, Li , McCollum, Sarah , Li, Jinxiu , Jones, Caelen A. , Wagner, Lena , Dalal, Vineet , Golde, Viola , Pejkovska, Anastasija , Carroll, Lara , Haldar, Malay , Pollack, Seth M. , Lowe, Scott W. , Nielsen, Torsten O. , Banito, Ana and Jones, Kevin B.
Publisher
United States
Journal title
Language
English
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Publication information
Publisher
United States
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Scope and Contents
Contents
Synovial sarcoma is an aggressive soft tissue cancer driven by the chimeric SS18::SSX fusion oncoprotein, which disrupts chromatin remodeling by combining two antagonistic transcriptional regulators. SS18 participates in BAF complexes that open chromatin, while the SSX genes are cancer-testis antigens that interface with chromatin decorated with mo...
Alternative Titles
Full title
DNA demethylating agents suppress preclinical models of synovial sarcoma
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_3197640537
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_3197640537
Other Identifiers
ISSN
1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI190855
