Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
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Publisher
Washington, DC: American Society for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Society for the Advancement of Science
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Scope and Contents
Contents
The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/-mice displayed aberrant intestinal crypt morphology and altere...
Alternative Titles
Full title
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
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Record Identifier
TN_cdi_proquest_miscellaneous_35107882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_35107882
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1069094
