Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans
Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans
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Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here, we report that loss of VHL-1 significantly increased life span and enhanced resistance to pol...
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Full title
Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans
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Record Identifier
TN_cdi_proquest_miscellaneous_36184252
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_36184252
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1173507
