Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor...
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The mechanism of PDGF-receptor β (PDGFRβ) activation was explored by analyzing the properties of mutant receptors designed based on the crystal structure of the extracellular region of the related receptor tyrosine kinase KIT/stem cell factor receptor. Here, we demonstrate that PDGF-induced activation of a PDGFRβ mutated in Arg-385 or Glu-390 in D4...
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Full title
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
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TN_cdi_proquest_miscellaneous_47674042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_47674042
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.0802896105
