Donor-Specific Transplantation Tolerance: The Paradoxical Behavior of CD4+ CD25+ T Cells
Donor-Specific Transplantation Tolerance: The Paradoxical Behavior of CD4+ CD25+ T Cells
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
To investigate the antigen specificity of regulatory T cells capable of preventing transplant rejection, we have developed two different strategies to achieve tolerance to fully mismatched skin grafts in euthymic mice. A combination of nondepleting Abs targeting CD4, CD8, and CD154 (CD40 ligand) induces dominant transplantation tolerance to fully m...
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Full title
Donor-Specific Transplantation Tolerance: The Paradoxical Behavior of CD4+ CD25+ T Cells
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TN_cdi_proquest_miscellaneous_66685353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66685353
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0400084101
