Silent Information Regulator 2 Potentiates Foxo1-Mediated Transcription through Its Deacetylase Acti...
Silent Information Regulator 2 Potentiates Foxo1-Mediated Transcription through Its Deacetylase Activity
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2). Genetic studies demonstrate that Sir2 acts to extend lifespan in Caenorhabditis elegans upstream of DAF-16, a member of the FOXO family, in the insulin-like signaling pathway. However, the molecu...
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Full title
Silent Information Regulator 2 Potentiates Foxo1-Mediated Transcription through Its Deacetylase Activity
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TN_cdi_proquest_miscellaneous_66687498
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66687498
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0400593101
