Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to...
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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We have recently demonstrated that the pyrazolopyrimidines PP1 and PP2 and the 4-anilinoquinazoline ZD6474 display a strong inhibitory activity (IC
50
⩽100 n
M
) towards constitutively active oncogenic RET kinases. Here, we show that most oncogenic MEN2-associated RET kinase mutants are highly susceptible to PP1, PP2 and ZD6474 inhibiti...
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Full title
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
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TN_cdi_proquest_miscellaneous_66793356
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66793356
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1207810
