Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
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Author / Creator
Lara, E , Mai, A , Calvanese, V , Altucci, L , Lopez-Nieva, P , Martinez-Chantar, M L , Varela-Rey, M , Rotili, D , Nebbioso, A , Ropero, S , Montoya, G , Oyarzabal, J , Velasco, S , Serrano, M , Witt, M , Villar-Garea, A , Inhof, A , Mato, J M , Esteller, M and Fraga, M F
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) belong to the family of NAD+ (nicotinamide adenine dinucleotide-positive)-dependent class III histone deacetylases and are involved in regulating lifespan. As cancer is a disease of ageing, targeting Sirtuins is emerging as a promising antitumour strategy. Here we present Salermide (
N
-{3-[(2-hydroxy-n...
Alternative Titles
Full title
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
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Record Identifier
TN_cdi_proquest_miscellaneous_66919651
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_66919651
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2008.436
