Inhibition of Wnt signaling by Dishevelled PDZ peptides
Inhibition of Wnt signaling by Dishevelled PDZ peptides
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Dishevelled proteins are key regulators of Wnt signaling pathways that have been implicated in the progression of human cancers. We found that the binding cleft of the Dishevelled PDZ domain is more flexible than those of canonical PDZ domains and enables recognition of both C-terminal and internal peptides. These peptide ligands inhibit Wnt/β-cate...
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Full title
Inhibition of Wnt signaling by Dishevelled PDZ peptides
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TN_cdi_proquest_miscellaneous_67045255
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67045255
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.152
