Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
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Author / Creator
Yang, Xia , Deignan, Joshua L , Qi, Hongxiu , Zhu, Jun , Qian, Su , Zhong, Judy , Torosyan, Gevork , Majid, Sana , Falkard, Brie , Kleinhanz, Robert R , Karlsson, Jenny , Castellani, Lawrence W , Mumick, Sheena , Wang, Kai , Xie, Tao , Coon, Michael , Zhang, Chunsheng , Estrada-Smith, Daria , Farber, Charles R , Wang, Susanna S , van Nas, Atila , Ghazalpour, Anatole , Zhang, Bin , MacNeil, Douglas J , Lamb, John R , Dipple, Katrina M , Reitman, Marc L , Mehrabian, Margarete , Lum, Pek Y , Schadt, Eric E , Lusis, Aldons J and Drake, Thomas A
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Thomas Drake and colleagues report the results of knockout or transgene introduction for nine obesity candidate genes in mice. Eight of the nine mutations result in significant changes in obesity-related traits, validating their previously developed approach for identifying candidate genes involved in particular phenotypes. They further identify re...
Alternative Titles
Full title
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
Authors, Artists and Contributors
Author / Creator
Deignan, Joshua L
Qi, Hongxiu
Zhu, Jun
Qian, Su
Zhong, Judy
Torosyan, Gevork
Majid, Sana
Falkard, Brie
Kleinhanz, Robert R
Karlsson, Jenny
Castellani, Lawrence W
Mumick, Sheena
Wang, Kai
Xie, Tao
Coon, Michael
Zhang, Chunsheng
Estrada-Smith, Daria
Farber, Charles R
Wang, Susanna S
van Nas, Atila
Ghazalpour, Anatole
Zhang, Bin
MacNeil, Douglas J
Lamb, John R
Dipple, Katrina M
Reitman, Marc L
Mehrabian, Margarete
Lum, Pek Y
Schadt, Eric E
Lusis, Aldons J
Drake, Thomas A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_67082036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67082036
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.325
