Heterozygosity for the S180L Variant of MAL/TIRAP, a Gene Expressing an Adaptor Protein in the Toll‐...
Heterozygosity for the S180L Variant of MAL/TIRAP, a Gene Expressing an Adaptor Protein in the Toll‐Like Receptor Pathway, Is Associated with Lower Risk of Developing Chronic Chagas Cardiomyopathy
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Oxford: University of Chicago Press
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Language
English
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Oxford: University of Chicago Press
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Background. Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. Among T. cruzi–infected individuals, only a subgroup develops severe chronic Chagas cardiomyopathy (CCC); the majority remain asymptomatic. T. cruzi displays numerous ligands for the Toll‐like receptors (TLRs), which are an important component of innate immunity that...
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Full title
Heterozygosity for the S180L Variant of MAL/TIRAP, a Gene Expressing an Adaptor Protein in the Toll‐Like Receptor Pathway, Is Associated with Lower Risk of Developing Chronic Chagas Cardiomyopathy
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TN_cdi_proquest_miscellaneous_67276481
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67276481
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ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1086/599212
