HOXB4 confers a constant rate of in vitro proliferation to transduced bone marrow cells
HOXB4 confers a constant rate of in vitro proliferation to transduced bone marrow cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
HOXB4 overexpression mediates increased self-renewal of haematopoietic stem cells (HSCs)
ex vivo
. Since HOXB4-expanded HSCs retain normal differentiation potential and there is no leukaemia development from transduced HSCs, HOXB4 represents a promising tool for human HSC therapy. However, the increased proliferation capacity of HOXB4 overexp...
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Full title
HOXB4 confers a constant rate of in vitro proliferation to transduced bone marrow cells
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TN_cdi_proquest_miscellaneous_67364977
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67364977
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1208202
