A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates...
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Christopher Kirk and his colleagues have developed the first specific inhibitor of the immunoproteasome. They find that the immunoproteasome has a major role in regulating cytokine production, as well as antigen presentation, and their inhibitor has good efficacy in animal models of arthritis.
The immunoproteasome, a distinct class of proteasome...
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Full title
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
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TN_cdi_proquest_miscellaneous_67467716
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67467716
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1978
