Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyropho...
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates
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Publisher
England
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Language
English
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England
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Contents
In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1beta through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In contrast, M2 polarized macrophages are critical t...
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Full title
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates
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TN_cdi_proquest_miscellaneous_67510207
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67510207
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E-ISSN
1460-2075
DOI
10.1038/emboj.2009.163
