Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mi...
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Mice that lack the fission mitochondrial GTPase Drp1, are shown to die during embryonic development. Although Drp1 is not required for apoptosis, the absence of Drp1 leads to neuronal and synaptic defects due to a failure of elongated mitochondria to reach distal parts of axons.
Mitochondrial morphology is dynamically controlled by a balance bet...
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Full title
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
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TN_cdi_proquest_miscellaneous_67550949
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67550949
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1907
