Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells i...
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
About this item
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The stability of expression of the transcription factor Foxp3
in vivo
has not been thoroughly assessed. Bluestone and colleagues find that Foxp3 expression can be unstable and that cells that lose Foxp3 expression can assume a proinflammatory autoaggressive phenotype.
Regulatory T cells (T
reg
cells) are central to the maintenance of...
Alternative Titles
Full title
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
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TN_cdi_proquest_miscellaneous_67592851
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67592851
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.1774
