B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency s...
B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its receptor (BAFF-R). In mice, mutations in BAFF or BAFF-R cause B-cell lymphopenia and antibody deficiency. Analyzing BAFF-R expression and BAFF-binding to B cells in common variable immunodeficiency (CVID) patients, we identified two siblings carrying a homo...
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Full title
B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans
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Record Identifier
TN_cdi_proquest_miscellaneous_67611277
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67611277
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0903543106
