Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differe...
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
About this item
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Author / Creator
Hartmann, Christian , Meyer, Jochen , Balss, Jörg , Capper, David , Mueller, Wolf , Christians, Arne , Felsberg, Jörg , Wolter, Marietta , Mawrin, Christian , Wick, Wolfgang , Weller, Michael , Herold-Mende, Christel , Unterberg, Andreas , Jeuken, Judith W. M. , Wesseling, Peter , Reifenberger, Guido and von Deimling, Andreas
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
Subjects
More information
Scope and Contents
Contents
Somatic mutations in the
IDH1
gene encoding cytosolic NADP+-dependent isocitrate dehydrogenase have been shown in the majority of astrocytomas, oligodendrogliomas and oligoastrocytomas of WHO grades II and III.
IDH2
encoding mitochondrial NADP+-dependent isocitrate dehydrogenase is also mutated in these tumors, albeit at much lower freq...
Alternative Titles
Full title
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_67631882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67631882
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-009-0561-9
