Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocam...
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Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
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TN_cdi_proquest_miscellaneous_67669891
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67669891
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1122511
