The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neuro...
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Insulin action in the brain is known to inhibit food intake. Now Leona Plum and her colleagues show that in hypothalamic neurons insulin inhibits FoxO1-mediated transcriptional repression of
Cpe
, a gene that encodes a carboxypeptidase that is required for proper processing of key anorexigenic neuropeptides. The team also found that this path...
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The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
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TN_cdi_proquest_miscellaneous_67685849
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67685849
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2026
