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Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67716661

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

About this item

Full title

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

Publisher

New York, NY: Am Thoracic Soc

Journal title

American journal of respiratory and critical care medicine, 2005-04, Vol.171 (8), p.858-867

Language

English

Formats

Publication information

Publisher

New York, NY: Am Thoracic Soc

More information

Scope and Contents

Contents

The cascade of cellular and molecular pathways mediating acute lung injury is complex and incompletely defined. Although the Src and Jak family of kinases is upregulated in LPS-induced murine lung injury, their role in the development of lung injury is unknown. Here we report that systemic inhibition of these kinases using specific small molecule i...

Alternative Titles

Full title

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_67716661

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67716661

Other Identifiers

ISSN

1073-449X

E-ISSN

1535-4970

DOI

10.1164/rccm.200407-981OC

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