Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases
Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Numerous human diseases are associated with the chronic expression of misfolded and aggregation-prone proteins. The expansion of polyglutamine residues in unrelated proteins is associated with the early onset of neurodegenerative disease. To understand how the presence of misfolded proteins leads to cellular dysfunction, we employed Caenorhabditis...
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Full title
Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases
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TN_cdi_proquest_miscellaneous_67739048
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67739048
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1124514
