Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream...
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aberrant Wnt signaling, mainly through mutations of
APC
and in some cases of
CTNNB1
or
AXIN2
, has been found in the majority of colorectal cancers. Recently, frequent promoter hypermethylation was identified to cause silencing of the secreted frizzled-related protein (sFRP) family in colorectal cancer. Restoration of sFRP in colo...
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Full title
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
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TN_cdi_proquest_miscellaneous_67768598
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67768598
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1208511
