Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in norm...
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
About this item
Full title
Author / Creator
Kakeda, M , Hiratsuka, M , Nagata, K , Kuroiwa, Y , Kakitani, M , Katoh, M , Oshimura, M and Tomizuka, K
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Human artificial chromosomes (HACs) segregating freely from host chromosomes are potentially useful to ensure both safety and duration of gene expression in therapeutic gene delivery. However, low transfer efficiency of intact HACs to the cells has hampered the studies using normal human primary cells, the major targets for
ex vivo
gene thera...
Alternative Titles
Full title
Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_67803914
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67803914
Other Identifiers
ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/sj.gt.3302483
