A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Antigen stimulation of immune cells triggers Ca
2+
entry through Ca
2+
release-activated Ca
2+
(CRAC) channels, promoting the immune response to pathogens by activating the transcription factor NFAT. We have previously shown that cells from patients with one form of hereditary severe combined immune deficiency (SCID) syndrome are...
Alternative Titles
Full title
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_67961147
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_67961147
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature04702
