APOBEC3G DNA deaminase acts processively 3′ → 5′ on single-stranded DNA
APOBEC3G DNA deaminase acts processively 3′ → 5′ on single-stranded DNA
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Akin to a 'Trojan horse,' APOBEC3G DNA deaminase is encapsulated by the HIV virion. APOBEC3G facilitates restriction of HIV-1 infection in T cells by deaminating cytosines in nascent minus-strand complementary DNA. Here, we investigate the biochemical basis for C → U targeting. We observe that APOBEC3G binds randomly to single-stranded DNA, then ju...
Alternative Titles
Full title
APOBEC3G DNA deaminase acts processively 3′ → 5′ on single-stranded DNA
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_68033417
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68033417
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb1086
