Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac and lamellipodium protrusion. We show here that a unique clathrin heavy-chain repeat homology protein, FROUNT, directly bound activated CCR2 a...
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Full title
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis
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TN_cdi_proquest_miscellaneous_68061373
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68061373
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ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1222
