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Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil

Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68066400

Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil

About this item

Full title

Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil

Publisher

Berlin: Springer

Journal title

Archives of toxicology, 2005-07, Vol.79 (7), p.414-421

Language

English

Formats

Publication information

Publisher

Berlin: Springer

More information

Scope and Contents

Contents

In this preliminary study, the potential of an in utero-lactation assay to detect thyroid effectors was evaluated by treating three dams/group with 6-n-propyl-2-thiouracil (PTU), a known thyroid antagonist, by oral gavage at doses of 0, 0.0032, 0.016, 0.08 and 0.4 mg/kg/day during fetal organogenesis and lactation. Hearing disturbances and an eleva...

Alternative Titles

Full title

Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_68066400

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68066400

Other Identifiers

ISSN

0340-5761

E-ISSN

1432-0738

DOI

10.1007/s00204-004-0641-5

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