Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-β
Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-β
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-
β
induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-
β
to induce stress fibers and inhibit cell migration...
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Full title
Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-β
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TN_cdi_proquest_miscellaneous_68083730
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68083730
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1208688
