GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
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Author / Creator
Tegeder, Irmgard , Costigan, Michael , Griffin, Robert S , Abele, Andrea , Belfer, Inna , Schmidt, Helmut , Ehnert, Corina , Nejim, Jemiel , Marian, Claudiu , Scholz, Joachim , Wu, Tianxia , Allchorne, Andrew , Diatchenko, Luda , Binshtok, Alexander M , Goldman, David , Adolph, Jan , Sama, Swetha , Atlas, Steven J , Carlezon, William A , Parsegian, Aram , Lötsch, Jörn , Fillingim, Roger B , Maixner, William , Geisslinger, Gerd , Max, Mitchell B and Woolf, Clifford J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential cofactor for catecholamine, serotonin and nitric oxide production. After axonal injury, concentrations of BH4 rose in primary sensory neurons, owing to up...
Alternative Titles
Full title
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Authors, Artists and Contributors
Author / Creator
Costigan, Michael
Griffin, Robert S
Abele, Andrea
Belfer, Inna
Schmidt, Helmut
Ehnert, Corina
Nejim, Jemiel
Marian, Claudiu
Scholz, Joachim
Wu, Tianxia
Allchorne, Andrew
Diatchenko, Luda
Binshtok, Alexander M
Goldman, David
Adolph, Jan
Sama, Swetha
Atlas, Steven J
Carlezon, William A
Parsegian, Aram
Lötsch, Jörn
Fillingim, Roger B
Maixner, William
Geisslinger, Gerd
Max, Mitchell B
Woolf, Clifford J
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_68134851
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_68134851
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1490
